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The Hyped-Up Food Additive: Why Are Indians Obsessed with Papain?

September 12, 2023

Have you ever come across a curious news story about how Indians love growing papayas and, even when the fruit is still unripe, they make cuts all over it? In just seconds, a milky white liquid oozes from the papaya, and the locals quickly collect it in containers to sell. In some parts of India, people even make a living off of this papaya sap. So, why do people slice into the unripe papaya to gather this white liquid? What makes it so valuable? It turns out that the process of cutting into an unripe papaya and collecting the milky sap is highly specialized. This variety of papaya is not the edible kind—its nutritional value is low, but its economic value is high. The fruit doesn’t need to fully ripen. Once it grows large enough, people cut into its surface, and the papaya releases that milky substance, known as papain. Papain is a proteolytic enzyme, meaning it breaks down proteins, and it has protease activity. Papain isn’t just popular in Southeast Asia—it has a similarly elevated status in China, where...

The Amazing Bromelain

The Amazing Bromelain

September 12, 2023

Bromelain is a natural plant enzyme extracted from the fruit, leaves, and stem of pineapples. It is widely used in both the food and pharmaceutical industries. Bromelain is a glycoprotein composed of various enzymes with different molecular weights and structures, including at least five types of proteolytic enzymes. In addition, it may contain phospholipases, peroxidases, cellulases, other glycosidases, and non-protein substances. It is more effective than the body's own proteases at breaking down food proteins in the digestive tract and can increase the permeability of the intestinal mucosa, aiding in the absorption and utilization of amino acids. Bromelain has many medical applications. Its first use in medicine was in 1957, when it was successfully applied to inhibit certain inflammatory metabolites that would otherwise accelerate and worsen inflammatory responses. Bromelain is an anti-inflammatory agent without the side effects typically associated with drugs. It is used for sports injuries, trauma, arthritis, and other types of swelling. Its primary applications include treatment for sports injuries, gastrointestinal issues, phlebitis, sinusitis, and post-surgical recovery. A dosage of 200 mg of bromelain has been shown to...

Why does eating pineapple make your mouth tingle? What is bromelain, and what does it do?

September 12, 2023

Are you afraid of fruit? Some people might find it strange: fruit is sweet and tangy, so what’s there to fear? For me, the fruit I fear the most is pineapple. This is because when I was a kid, eating pineapple always left my mouth feeling prickly and numb; once, it even made me bleed… This experience left a significant psychological mark on my young mind. As I grew up, I learned that this was all due to a substance in pineapples—bromelain. This "painful" little guy showed up on health supplement shelves one day?! What’s going on here? What is Bromelain? Pineapple is a fruit native to South America and is an important part of traditional Hawaiian medicine. It’s one of the richest sources of bromelain in the world. Bromelain consists of several endopeptidases and compounds, such as phosphatases, glucosidases, peroxidases, cellulases, carboxypeptidases, and protease inhibitors. Our star today—bromelain—isn’t extracted from the flesh of the pineapple due to its low content but from the stem or core of the pineapple. In folk medicine, pineapple is widely used to treat various...

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